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pentobarbital will reduce the extent or effect of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with powerful CYP3A4 inducers isn't proposedpentobarbital will decrease the level or effect of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Observe Carefully (one)pe